The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Biology Consortium, 2017Characterization of Leukocytes as Biomarkers for LRRK2 and Autophagy in Parkinson's Disease
Study Rationale:
To avoid accumulation of products that may cause toxicity, neurons rely on a series of highly efficient mechanisms of quality control. It has been proposed that, in those with...
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Target Advancement Program, 2017Neuroprotective Effects of Endosulfine-alpha in Parkinson's Disease
Study Rationale:
Evidence suggests that alpha-synuclein can cause neuron death in Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small structures inside the cell called... -
Target Advancement Program, 2017Validation of USP30 as a Therapeutic Target for Parkinson's Disease Modification
Study Rationale:
Mitochondria provide energy for neurons to function and survive. Evidence suggests that individuals with Parkinson's disease (PD) have poorly functioning mitochondria, such that the... -
Target Advancement Program, 2017Farnesoid X Receptor to Reduce Neuroinflammation
Study Rationale:
Although the precise mechanism(s) for neurodegeneration in Parkinson's disease (PD) is unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we... -
Research Grant, 2016Antibody Development for Modified Parkin Proteins Identified in the Human Brain
Study Rationale:
The PARK2 gene encodes the Parkin protein. It is one of three genes that protect from young-onset Parkinson disease (PD); in Parkin's absence, symptoms and signs usually begin before... -
Target Advancement Program, 2016Validation of the 18kDa Translocator Protein as a Novel Immunomodulator to Slow Progression in Parkinson's Disease
Study Rationale:
The immune system in the brain has two distinct modes: mode one is fighting infection and mode two is repairing injured nerve cells. In Parkinson's disease (PD), we think that the...
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Our funding programs support basic, translational and clinical research from academia and industry.