The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Fast Track, 2001PET Neuroimaging Study of the Brain Serotonin Transporter in Parkinson's Disease: Relationship to Clinical Depression
Approximately 40% of patients with Parkinson's disease (PD) suffer from depression, which in many cases is more disabling than the impairment of motor function. Since the original discovery by Oleh...
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Proof-of-Concept Testing of PD Therapeutics, 2022Therapeutic Targeting of Mitochondrial Biogenesis to Address Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is a complex disorder involving the degeneration of specific brain cells that lead to severe impairments in movement and cognition. Although the exact cause...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Assessment of IRL757 for the Treatment of Apathy in Parkinson's Disease
Study Rationale: People with Parkinson’s disease (PD) frequently develop a loss of motivation and initiative. Such apathy can be burdensome for patients and their families and caregivers and is...
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LRRK2, 2011fMRI of First Degree Relatives of LRRK2 Positive Parkinson's Disease Patients
Objective/Rationale:
First, to study the effect of the presence of the LRRK2 G2019S mutation on brain activation patterns in PD patients who recently converted into a diseased state by comparing... -
Target Validation, 2011Preferential Targeting of Subpopulations of 5-HT1A Receptors
Objective/Rationale:
Although Parkinson's disease (PD) is primarily caused by dopamine dysfunction, function of serotonin (another neurotransmitter) is also affected. This suggests that serotonergic... -
LRRK2 Cohort Consortium Resource Request, 2013Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene
Objective/Rationale:
Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called...
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