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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2014
    Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target

    Objective/Rationale:
    Defects in mitochondria (the “powerhouse” of the cell) are implicated in Parkinson’s disease (PD), and the protein parkin is known to be involved in controlling mitochondrial...

  • PPMI Sample Request, 2014
    Whole Blood RNA Biomarkers of Parkinson’s Disease

    Objective/Rationale:
    When a Parkinson’s disease patient first experiences motor symptoms, most of the neurons in the part of the brain affected by the disease have already died and therefore the...

  • Research Grant, 2014
    Role of LRRK2 in Dopamine Modulation of Striatal Glutamate Transmission

    Objective/Rationale: 
    Many of the motor symptoms in Parkinson’s disease (PD) are attributed to a deficit of the neurotransmitter dopamine in the brain region called the striatum. Recent studies show...

  • Target Validation, 2014
    CISD1 (mitoNEET) as a Mitochondrial Drug Target in Parkinson’s Disease

    Objective/Rationale:
    Mitochondrial dysfunction and oxidative stress contributes to the death of the brain cells seen in Parkinson’s disease. The mitochondrial protein mitoNEET (encoded by the gene...

  • Parkin Therapeutic Development, 2014
    Pharmacological Modulation of Parkin Expression and Function to Attenuate Mitochondrial Dysfunction

    Objective/Rationale:
    This project aims to identify drug-like molecules that increase the amount of the protein parkin in neuronal cells. Parkin is mutated in some people with Parkinson’s disease (PD)...

  • Rapid Response Innovation Awards, 2014
    Regulation of Alpha-synucleinopathy by BPOZ-2

    Objective/Rationale:             
    BPOZ-2 is an anti-tumor protein that has been reported to stimulate the removal of cancer- related protein aggregates in cancer cells. However, its role has never been...

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