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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2014
    siRNA Screen of Microglia to Identify Neuroprotective Drug Targets in Parkinson´s Disease

    Objective/Rationale:             
    Neuroinflammation is a fundamental process contributing to the death of neurons in Parkinson´s disease (PD). During this process, inflammatory microglia, which are the...

  • Rapid Response Innovation Awards, 2014
    Mirtazapine as a Treatment for Pathological Gambling

    Objective/Rationale:             
    Pramipexole (Mirapex®) is a drug that is effective at alleviating movement deficits associated with Parkinson’s disease. However, pramipexole can induce compulsive...

  • Rapid Response Innovation Awards, 2014
    Pum2-mediated Translational Regulation of Alpha-synuclein mRNA Associated with Mitochondria

    Objective/Rationale:             
    Aggregation of the protein alpha-synuclein and dysfunction of mitochondria (the powerhouse of the cell) are two critical components of Parkinson’s disease. We have...

  • Research Grant, 2014
    Bioenergetic and Proteomic Profiling of PINK1, DJ-1 and Parkin Models

    Objective/Rationale:
    Some forms of familial Parkinson’s disease (PD) are due to mutations in the genes that code for the proteins PINK1, DJ-1 and parkin. These proteins have specific roles in the...

  • Parkin Biology, 2014
    Function of Parkin-mediated Ubiquitination in Synaptic Function

    Objective/Rationale:             
    Researchers know that the protein parkin is associated with Parkinson’s disease (PD), but need to know more about its pathways and processes to target it with...

  • Parkin Biology, 2014
    Parkin Modulates Neuroinflammation to Sustain Dopaminergic Neuronal Health

    Objective/Rationale: 
    People with mutations in the Parkin gene can develop young-onset Parkinson’s disease (PD). The protein parkin (genes encode proteins) modifies the structure of many other cell...

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