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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2014
    Saliva Alpha-synuclein Levels in LRRK2 Mutation Carriers

    Study Rationale:       
    Biomarkers are needed to assist with the diagnosis of Parkinson’s disease (PD) and with monitoring its progression. Decreased levels of alpha-synuclein in cerebrospinal fluid...

  • Therapeutic Pipeline Program, 2014
    Optimization of Dopamine D4 Antagonists for the Treatment of Levodopa-induced Dyskinesia

    Study Rationale:                   
    Levodopa-induced dyskinesia is a major dose-limiting effect associated with long-term treatment of Parkinson’s disease (PD). There are no effective treatments for...

  • Biomarkers Across Neurodegenerative Diseases, 2014
    Subcortical Shape Analysis for Joint Biomarker Discovery

    Study Rationale:                   
    We know that both Alzheimer’s and Parkinson’s diseases affect certain parts of the brain first, before affecting the rest of the brain, and often before people start...

  • Research Grant, 2014
    Retinal Pathology in Parkinson’s Disease: Implications for Vision and Biomarkers

    Study Rationale:                   
    Vision problems are not what most of us think of when we think of Parkinson’s disease (PD), but there are some physical changes in the retina of people with PD...

  • Research Grant, 2014
    Development of a Biomarker Assay for Oxidized DJ-1 in Parkinson’s Disease

    Study Rationale:                   
    Mutations in the DJ-1 gene cause an early-onset form of Parkinson’s disease (PD). The DJ-1 protein is an attractive biomarker for sporadic PD, as well, since it is...

  • Research Grant, 2014
    Role of Phosphodiesterase 10A in Early Sporadic Parkinson’s Disease

    Study Rationale:                   
    We have collected preliminary data from people who were recently diagnosed with Parkinson's disease (PD), which show that an enzyme called phosphodiesterase 10A (PDE...

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