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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2013
    Validation of a Novel Pre-Clinical Model of Dyskinesia in PD

    Promising Outcomes of Original Grant:
    Our original target validation grant was aimed at deciphering the role of the protein beta-arrestin2 in the manifestation of beneficial versus dyskinetic side...

  • Rapid Response Innovation Awards, 2013
    Topography of Vulnerability to Alpha-synuclein Fibrils in the Cerebral Cortex

    Objective/Rationale:             
    In Parkinson’s disease, the neocortex (outer layer of the brain’s cerebral hemispheres, made of six layers) is less vulnerable than the allocortex (fewer than six...

  • Rapid Response Innovation Awards, 2013
    Genetic Validation of a New Causative Gene for Familial and Sporadic Parkinson’s Disease

    Objective/Rationale:             
    Genetic and environmental factors both have been linked to Parkinson’s disease (PD). Over the last 15 years, many PD susceptibility genes have been described. However...

  • Target Validation, 2013
    The Role of the Protein FBXO7 in Parkinsonism

    Objective/Rationale:             
    Increasing evidence points to an important role of genetics in Parkinson’s disease (PD). Causative mutations (alterations in the DNA sequence) have been found in many...

  • Therapeutic Pipeline Program, 2013
    Study to Evaluate RM-131 Administered to Parkinson’s Patients with Chronic Constipation

    Objective/Rationale:             
    The purpose of this study, called MOVE-PD, is to investigate how patients with Parkinson’s disease (PD) and chronic constipation respond to the drug RM-131. The study...

  • LRRK2 Target Engagement Ligand, 2013
    LRRK2 Target Engagement Ligand (Supplement)

    Promising Outcomes of Original Grant:
    New compounds from several distinct series have been synthesized that have improved inhibition of the LRRK2 enzymatic kinase activity. We assessed their...

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