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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Postural Instability and Gait Disturbances, 2009
    Determining the Neural Correlates of Freezing of Gait in Parkinson's Disease Using Functional Magnetic Resonance Imaging

    Objective/Rationale:
    Freezing of Gait (FOG) in Parkinson’s disease occurs when a person’s feet become suddenly ‘frozen’ while walking or turning. FOG is a leading cause of falls, and responds poorly to...

  • Clinical Intervention Awards, 2007
    Serotonin and Sleep Disordered Breathing in Parkinson Disease

    Objective/Rationale:
    Sleep related problems are a major cause of impairment in Parkinson's disease. Recent studies indicate a high incidence of a disabling sleep disorder – sleep disordered breathing...

  • Biomarkers Across Neurodegenerative Diseases, 2014
    Cortical and Functional Distinctions in Alzheimer’s and Parkinson’s Diseases

    Study Rationale:
    Alzheimer’s disease (AD) and Parkinson’s disease (PD) are clinically distinct disorders, but their pathologies overlap considerably. Understanding how these overlaps relate to the two...

  • Alpha-synuclein Pathology, 2014
    Contrasting Pathological Versus Normal Alpha-synuclein Assemblies

    Study Rationale:                   
    Parkinson’s disease (PD) is characterized by Lewy bodies composed of the protein alpha-synuclein in dopamine-producing nerve cells. The protein aggregates are also...

  • Research Grant, 2024
    Validation of Functional Staging of Parkinson’s Disease Using the Critical Path for Parkinson’s (CPP) Integrated Parkinson’s Database

    Study Rationale: Researchers recently proposed defining Parkinson’s disease (PD) based on a test for abnormal alpha-synuclein in spinal fluid and adopting a staging system based on measures (or scales...

  • Community Fast Track, 2004
    The role of nociceptin/orphanin FQ in regulation of motor behavior and induction of parkinsonism

    Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide discovered in the mid 90's, which activates a G-protein coupled receptor, the NOP receptor. N/OFQ and its receptor are diffusely expressed...

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