The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013Comprehensive Structural and Molecular Phenotyping of Parkinson’s Disease Models
Objective/Rationale:
Parkinson’s disease (PD) pre-clinical models carrying relevant human PD gene mutations can provide important insights into the molecular mechanisms implicated in PD... -
LRRK2 Cohort Consortium Resource Request, 2013Peripheral Blood-based Transcript Biomarkers for Prediction of Parkinson Disease in LRRK2 Mutation Carriers
Objective/Rationale:
Currently, there is no known marker that can be found in the human blood that can help to predict Parkinson's disease (PD). There is also no marker that can help... -
LRRK2 Pharmacodynamic Assays, 2013Fluorescence Fluctuation Spectroscopy Assays to Monitor the Activity of LRRK2
Objective/Rationale:
LRRK2 is a major protein target for therapeutic treatment of Parkinson’s disease (PD). The lack of assays (experiment set-ups) available for measuring the activity of... -
LRRK2 Cohort Consortium Resource Request, 2013Analysis and Replication of a Genetic Interaction between LRRK2 and PARK16
Study Rationale:
We previously showed that variants in two known Parkinson’s disease (PD) genes, LRRK2 and PARK16, genetically interact to increase risk of disease. Learning more about genetic variants... -
LRRK2 Cohort Consortium Resource Request, 2013Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene
Objective/Rationale:
Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called... -
LRRK2 Cohort Consortium Resource Request, 2013Influence of Immune Subtypes on the LRRK2 Phenotype
Study Rationale:
There is growing evidence for a relevant influence of chronic and subtle inflammation on Parkinson’s disease (PD). The most common causes of monogenic (involving one gene) PD are...
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