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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • RRIA 2012 (Rapid Response Innovation Awards), 2012
    Novel Protease Pathway in Parkinson’s Disease

    Objective/Rationale:
    Mitochondria are essential for generating energy for all the cells in the human body.  Many human diseases are caused by malfunctions in mitochondria, including Parkinson’s...

  • Rapid Response Innovation Awards, 2012
    Enzymatic Degradation of Brain Complex Gangliosides to Increase Endogenous GM1 Levels: Potential Neuroprotective/Neurorestorative Therapy for Parkinson’s disease

    Objective/Rationale:
    Pre-clinical studies and clinical studies with GM1 ganglioside in Parkinson’s disease patients suggest potential symptomatic and disease modifying effects of GM1 on Parkinson’s...

  • LRRK2 Cohort Consortium, 2012
    Parkinson’s Institute LRRK2 Cohort: Clinical Phenotype, Pre/Non-Motor and Environmental Risk Assessment

    Objective/Rationale:
    The objective of this award is to better understand the clinical symptoms of patients that carry the most common genetic risk factor for PD the LRRK2 G2019S variant and what role...

  • Rapid Response Innovation Awards, 2012
    Nigrostriatal Alpha-Synuclein Over-Expression in Young and Aged Pre-Clinical Models

    Objective/Rationale:
    Accurate pre-clinical models of Parkinson’s disease are needed in order to test novel therapies as well as to further our understanding of the disease itself. The molecule alpha...

  • MJFF Research Grant, 2012
    Generation of Phospho-Ser65 Parkin and Phospho-Thr257 PINK1 Pre-clinical Monoclonal Antibodies and Characterization of Total PINK1 Pre-clinical Monoclonal Antibodies

    Objective/Rationale:
    Mutations in an enzyme known as PINK1 can cause Parkinson’s disease. There has been
    great interest in understanding the function of PINK1 since uncovering the pathways that
    PINK1 is...

  • MJFF Research Grant, 2012
    Design of HdAd Type 5 LRRK2 Expression Vectors

    Objective/Rationale:
    LRRK2 is a gene that is has been implicated in Parkinson’s disease. LRRK2 is a large cDNA of approximately 7.6 kb that precludes it from being expressed in viral vectors such as...

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