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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2012
    Development of Nurr1-RXR Heterodimer Selective Agonists for Parkinson's Disease

    Promising Outcomes of Original Grant:
    We hypothesized that Nurr1 could be targeted indirectly with small molecules through other nuclear hormone receptors, and that such compounds would have...

  • Alpha-synuclein Biology Challenge, 2012
    Alpha-synuclein as a Major Regulator of Iron Homeostasis

    Objective/Rationale:                    
    Alpha-synuclein is a key protein involved in Parkinson’s disease. Attempts have been made with drugs to lower the amount of this protein in the brain as a...

  • LRRK2 in the Immune System, 2012
    Parkinson's and Inflammatory Bowel Diseases: Interaction in LRRK2 Transgenic Pre-clinical models

    Objective/Rationale:             
    Mutations in LRRK2 are the most common cause of genetic PD. LRRK2 has also been recently linked to inflammatory bowel diseases (IBD), such as Crohn’s and ulcerative...

  • Rapid Response Innovation Awards, 2012
    Effect of Tyrosine on Orthostatic Hypotension in Parkinson’s Disease

    Objective/Rationale: 
    Orthostatic hypotension is a sudden drop in blood pressure (BP) when an individual changes position. Individuals with Parkinson’s disease (PD) commonly suffer from orthostatic...

  • Rapid Response Innovation Awards, 2012
    Investigation of the Mechanisms Involved in Alpha-synuclein Secretion In Vivo

    Objective/Rationale:             
    Extracellular alpha-synuclein appears to be central in the pathogenesis, and perhaps progression of PD. The mechanism(s) underling alpha-synuclein secretion are...

  • MJFF Research Grant, 2012
    Consortium to Identify LRRK2 Modifiers of Age of Onset

    Objective/Rationale:             
    We propose to design and complete a collaborative study that will bring together data and samples from subjects with LRRK2 mutations with the express goal of...

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