The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Research Grant, 2013CLFB-113: MLK3 Inhibition in Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
Previously inhibitors of mixed lineage kinase 3 (MLK3) showed great promise for treatment of Parkinson’s disease in pre-clinical models, but interest in this area... -
Rapid Response Innovation Awards, 2013Alpha-Synuclein Effects on Fusion Pore Expansion and Protein Secretion
Objective/Rationale:
Alpha-synuclein, implicated in Parkinson’s disease, is normally expressed in nerve terminals, from which neurotransmitters are released by fusion of their granule membrane with the... -
Therapeutic Pipeline Program, 2013Synthetic Nurr1 Ligands as Novel Neuroprotective Therapeutics to Treat Parkinson’s Disease
Objective/Rationale:
The orphan nuclear receptor Nurr1 plays a critical role in the development and maintenance of midbrain dopamine neurons. Recent research also shows that it protects... -
Target Validation, 2013IL-13Ra1 and Neuroinflammatory Damage in the MPTP Pre-Clinical Model of PD
Study Rationale:
Neuroinflammation has been proposed to contribute to both the pathogenesis and the progression of Parkinson's disease (PD). We recently showed that an important... -
Cognition Biomarkers, 2013Validation of Novel and Traditional Quantitative EEG Biomarkers
Objective/Rationale:
Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD... -
LRRK2 Challenge, 2013Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
Objective/Rationale:
Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.