The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2011Direct Reprogramming of Cells into Dopamine Neurons
Objective/Rationale:
The availability of dopaminergic neurons for in-depth study or therapeutic replacement approaches has traditionally been limited. We aim to reprogram cells into dopaminergic... -
Rapid Response Innovation Awards, 2011Whole Exome Sequencing in an Amish Parkinson's Disease Pedigree
Objective/Rationale:
Although there is strong evidence to suggest genetics plays a role in Parkinson’s disease, the majority of the genes involved in Parkinson’s disease remain unidentified. We... -
Research Grant, 2010Symptoms and Side Effects of LRRK2 Mutation Carriers and Assessment of Factors Influencing LRRK2-related PD Expression
Objective/Rationale:
By incorporating our Spanish LRRK2 cohort with G2019S and R1441G mutations into the existing LRRK2 Cohort Consortium (L2CC) of people of Ashkenazi Jewish and North African Arab... -
MJFF Research Grant, 2010Development of Selective LRRK2 Inhibitors
Objective/Rationale:
LRRK2 kinase has been implicated as a potential therapeutic target for the treatment of Parkinson’s disease. The goal of our project is to make experimental drugs to test whether... -
LRRK2 Target Engagement Ligand, 2011Evaluating Novel Small Molecule Inhibitors of LRRK2 to Deliver PET Ligands
Objective/Rationale:
The exciting discovery of activating mutations in the LRRK2 kinase in familial PD patients, coupled with the emergence of kinase inhibitors as a new class of efficacious drugs... -
Rapid Response Innovation Awards, 2011Developing a Human Neural Model for Parkinson's Disease
Objective/Rationale:
Advances in the knowledge and treatment of Parkinson’s disease (PD) are limited by the inability to obtain, grow and study neural cells from the brains of living patients. Small...
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Our funding programs support basic, translational and clinical research from academia and industry.