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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutics Development Initiative, 2011
    Next Generation Parkinson's Disease Treatment through Steering Brain Stimulation (NEXT)

    Objective/Rationale:
    Deep Brain Stimulation (DBS) can provide a radical improvement in the quality of life of Parkinson’s patients. However, it is a complex procedure with a large incidence of...

  • Therapeutics Development Initiative, 2011
    Characterization of NPT001-mediated Alpha-Synuclein Disaggregation and Clearance

    Objective/Rationale:
    Abnormal accumulation of alpha-synuclein in the brain is associated with toxicity and disease progression in Parkinson’s and other neurodegenerative diseases. NPT001 has been...

  • Target Validation, 2011
    The Unfolded Protein Response (UPR) Chaperone GRP78/BiP as a Therapeutic Target for Alpha-Synuclein Toxicity

    Objective/Rationale:
    Glucose regulating protein 78 (GRP78/BiP), also known as BiP or HSPA5, is a member of the HSP70 family of chaperones. Along with its role in protein folding, GRP78/BiP is also...

  • Target Validation, 2011
    Modulation of Microglial Activation

    Objective/Rationale:
    Over-activation of immune cells in the brain can lead to increased neuron loss in diseases such as Parkinson’s. Fractalkine is a protein that is a key player in controlling...

  • MJFF Research Grant, 2011
    Increasing the Sensitivity of LRRK2 Assays: Development of Proximity Ligation Assays for LRRK2

    Objective/Rationale:
    Inherited mutations in the enzyme LRRK2 are known to cause Parkinson’s disease (PD). Measuring the enzyme activity of LRRK2 in patient biological samples is difficult due to the...

  • Rapid Response Innovation Awards, 2011
    How Does GBA1 Dysfunction Influence Parkinson's Disease?

    Objective/Rationale:
    Recent studies have revealed that defects in a gene known as GBA1 are the most common genetic cause of Parkinson’s disease (PD). The GBA1 gene is known to play a role in fat...

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Our funding programs support basic, translational and clinical research from academia and industry.

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