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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2011
    Regulatory T Cells as Modulators of Microglia's Inflammatory Response

    Objective/Rationale:
    Evidence in humans and in research models support a role for the immune system in the progression of Parkinson's disease. Local brain immune cells, called microglia, as well as...

  • Clinical Intervention Awards, 2011
    First-in-human Trial to Assess the Safety and Tolerability of PD01, the First Alpha-synuclein-based AFFITOPE® Parkinson's Vaccine

    Objective/Rationale:
    Parkinson’s disease (PD) is characterized by the presence of protein aggregates called Lewy bodies, with a major component of the protein alpha-synuclein. This fact and...

  • Rapid Response Innovation Awards, 2011
    Drug Rescue of PINK1 Kinase Activity - A New Therapeutic Modality For Treating PD

    Objective/Rationale:
    Many genetic disorders are caused by the loss of a functional protein which protects cells from disease. These disorders are difficult to treat with drugs because most drugs...

  • Target Validation, 2011
    Targeting of Alpha-synuclein and SNARE Complex Dysfunction to Restore Synaptic Dopamine Release in a Model of Parkinson Disease Pathology

    Objective/Rationale:
    Research data has recently indicated that pathology in Parkinson’s disease (PD) starts at the synapse, the part of the neurons where the release of dopamine occurs, dysfunction of...

  • MJFF Research Grant, 2011
    Identification of a Novel Calcium Selective Antagonist for Neuroprotection in PD

    Objective/Rationale:
    Nothing is known to slow or stop the progression of Parkinson’s disease. Our work and that of others suggests that antagonism of calcium channels having a Cav1.3 pore forming...

  • LRRK2, 2011
    14-3-3s as Regulators of LRRK2 Toxicity

    Objective/Rationale:
    This project will evaluate the functional consequences of the interaction between 14-3-3 proteins and LRRK2. 14-3-3 proteins play a crucial role in inhibiting cell death pathways...

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