The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2012Evaluation of PD-linked Transcripts in PPMI
Objective/Rationale:
Confirm associations between the expression of three susceptibility genes and Parkinson’s in peripheral blood of individuals with early-stage, untreated disease, and... -
MJFF Research Grant, 2012In Vivo Characterization of Helper-dependent Adenoviral Vectors Expressing Human LRRK2
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial Parkinson’s disease. Familial LRRK2 mutations induce neuronal toxicity in vitro. Reliable pre-clinical... -
Neurotrophic Factors Challenge, 2012Novel Cell-based Strategy for GDNF Delivery in Parkinson's Disease
Objective/Rationale:
Glial cell line-derived neurotrophic factor (GDNF) is the most potent nerve cell growth molecule capable of protecting the dopamine neurons that are affected in... -
LRRK2 in the Immune System, 2012Investigation of Neuroinflammation in LRRK2 Mutation Carriers Using Positron Emission Tomography
Objective/Rationale:
There is evidence that LRRK2 mutation may alter the immune response in such as way as to potentiate neuroinflammatory responses to external triggers, with a... -
Rapid Response Innovation Awards, 2012Targeting of 5-HT1A and 5-HT2A Receptors Against Levodopa-induced Dyskinesia
Objective/Rationale:
Levodopa continues to be the gold-standard therapy for patients with Parkinson’s disease (PD). Unfortunately, effective long-term treatment is beset by abnormal... -
Biomarker Development, 2012VILIP-1 as Diagnostic and Prognostic Biomarker for Parkinson's Disease
Objective/Rationale:
Novel biomarkers are key for successful clinical development of Parkinson’s therapies. In Alzheimer’s disease the calcium sensing protein VILIP-1 (visinin-like...
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Our funding programs support basic, translational and clinical research from academia and industry.