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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2011
    Targeting Glia in PD with Novel Anti-inflammatory Therapeutics

    Objective/Rationale: 
    Loss of dopamine-producing neurons in Parkinson’s disease (PD) is accompanied by inflammation in surrounding support cells, called glial cells. This inflammatory state in glial...

  • LRRK2 Target Engagement Ligand, 2011
    Development of LRRK2 Target Engagement Ligands

    Objective/Rationale: 
    The overall objective of this project is to generate the data necessary to ultimately identify a small organic molecule capable of binding to a sub-domain of the LRRK2 protein...

  • MJFF Research Grant, 2011
    Development of Functional Imaging for CB-1 and 5-HT1a in PD Participants with Dyskinesia

    Objective/Rationale:
    The goal of this proposal is to develop two imaging tests, [18F]MK-9470 and [18F]MPPF, to assess the function of two receptors (cannabinoid – CB-1 and serotonin receptor – 5-HT1a...

  • MJFF Research Grant, 2011
    Evaluation of LRRK2-derived Bioportides as Functional Protein Modulators and Potential Therapeutics

    Objective/Rationale: 
    The therapeutic actions of most existing drugs are the result of their binding to molecules known as proteins that are associated with certain cells of the human body. However...

  • MJFF Research Grant, 2011
    Analysis of Adhesion and Chemotactic Factor Expression Possibly Involved in T Cell Brain Extravasation in Parkinson's Disease: A Human Postmortem Analysis

    Objective/Rationale: 
    Brain infiltration of T cells has been identified in patients with Parkinson's disease and implicated in neurodegeneration in pre-clinical models. We hypothesize that peripheral T...

  • MJFF Research Grant, 2011
    Assessing and Diagnosing Anxiety in Patients with Parkinson's Disease

    Promising Outcomes of Original Grant:
    A previous MJFF sponsored study showed that the available anxiety questionnaires are not suitable to assess anxiety in Parkinson’s disease (PD). The different...

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Our funding programs support basic, translational and clinical research from academia and industry.

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