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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Defining Cognitive Phenotypes of Parkinson’s Disease, 2011
    Neurochemical Correlates of Cognitive Phenotypes in PD

    Objective/Rationale:
    Parkinson’s disease causes neurodegeneration in multiple subcortical nuclei, including substantia nigra, locus coeruleus, dorsal raphe nucleus, and nucleus basalis. Each of these...

  • Target Validation, 2011
    TGF-beta Signaling as Novel Therapeutic Treatment for Parkinson's Disease

    Objective/Rationale:
    Finding ways to protect dopaminergic neurons from degeneration could provide new therapies for Parkinson’s disease (PD). Transforming growth factor betas (TGF-betas) are essential...

  • Therapeutics Development Initiative, 2011
    Development of Posiphen to Treat Parkinson's Disease

    Objective/Rationale:
    Posiphen is a small molecule drug that inhibits expression of alpha-synuclein, a protein involved in Parkinson's disease (PD) pathogenesis. We propose studies in a pre-clinical...

  • Target Validation, 2011
    Validation of Skp1 as a New Target for PD Therapy

    Objective/Rationale:
    Multiple evidence supports the notion that a malfunction of the ubiquitin-proteasome system and autophagy plays a crucial role in protein misfolding and aggregation in Parkinson...

  • LRRK2, 2011
    DAT Imaging in Unaffected LRRK2 Gene Positive Subjects in a Chinese Community Cohort

    Objective/Rationale:
    While most PD is not associated with a specific genetic cause, the genetic mutation affecting the LRRK2 gene has been identified as a cause of PD in selected families and...

  • MJFF Research Grant, 2011
    Laboratory Phenotyping of Parkinson Disease Subjects Using a Multiplex Approach

    Promising Outcomes of Original Grant:
    With the original funded grant we have successfully optimized the measurement of total alpha-synuclein and DJ-1 in cerebrospinal fluid as promising markers for...

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Our funding programs support basic, translational and clinical research from academia and industry.

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