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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2011
    Comparing Cognitive Scales in the MUSTARDD-PD Study

    Objective/Rationale:
    Some people with Parkinson’s may develop dementia during their disease course. Being able to detect problems with mental function at an early stage, to monitor and to reliably...

  • Rapid Response Innovation Awards, 2011
    Testing Novel Compounds for Noninvasive Delivery of Small Interfering RNA into CNS

    Objective/Rationale:

    Small interfering RNA (siRNA) molecules have been successfully used to target specific genes in cell culture. However, the lack of specificity for siRNA to cells and lack of...

  • MJFF Research Grant, 2011
    Phenotypic Characterization of BAC LRRK2 Transgenic Pre-clinical Models

    Objective/Rationale:

    Mutations in the protein leucine-rich repeat kinase 2 (LRRK2) are the most common cause of inherited Parkinson’s disease (PD). Interestingly, the penetrance LRRK2 mutations and...

  • Rapid Response Innovation Awards, 2011
    Fractalkine-CX3Cr1 Signaling in Models of Parkinson Disease: Quest for Novel Therapeutic Strategies

    Objective/Rationale: 
    Microglia, one of the key players in neuroinflammation, are increased in number and activated in the brains of Parkinson’s disease (PD) or pre-clinical models of PD. A recent...

  • Rapid Response Innovation Awards, 2011
    The Development of Novel Adeno-associated Virus Vectors for Intravenous Parkinson's Gene Therapy

    Objective/Rationale:
    As Parkinson disease progresses, a wide range of brain areas exhibit evidence of inflammation and degeneration, but presently no therapies exist that selectively target these...

  • Rapid Response Innovation Awards, 2011
    Developing and Characterizing Anti-Alpha-Synuclein Nanobodies from an Immune Phage Display Library

    Objective/Rationale:
    This project uses a novel approach to deal with alpha-synuclein, which accumulates abnormally in Parkinson’s disease (PD). Cutting-edge recombinant antibody technologies will...

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