The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Resource: Utilizing DATATOP Biospecimens, 2011Validation of Alpha-synuclein Oligomers as Biomarker for Parkinson’s Disease
Objective/Rationale:
We have reported recently higher levels of α-synuclein oligomers species in cerebral spinal fluid (CSF) from patients clinically diagnosed with Parkinson’s disease (PD) versus... -
MJFF Research Grant, 2011Modulation of Striatal Colinergic Neuronal Activity in LID
Objective/Rationale:
The role of striatal cholinergic interneurons (ChIs) in Parkinson’s disease and side effects of treatment like levodopa-induced dyskinesia (LID) have been poorly studied. We have... -
MJFF Research Grant, 2011The Role of Serotonergic and Dopaminergic Mechanisms and their Interaction in L-DOPA Induced Dyskinesias
Objective/Rationale:
Our group has previously shown that brain cells that normally produce serotonin, by taking up L-dopa and then releasing dopamine in an uncontrolled fashion, play a crucial role... -
Target Validation, 2011Tau Oligomers as a Potential Target for Treatment of Parkinson's Disease
Objective/Rationale:
Tau pathology is a prominent feature of synucleinopathies, such as Parkinson disease (PD) and dementia with Lewy Bodies (DLB). An emerging view in neurodegeneration is that... -
Rapid Response Innovation Awards, 2010Generation of a Novel Recombinant Protein Activator of GPR88
Objective/Rationale:
Dopamine replacement therapy activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a... -
Rapid Response Innovation Awards, 2010Circulating microRNAs as Biomarkers for Early Detection of Parkinson's Disease
Objective/Rationale:
MicroRNAs (miRNAs) are small, conserved RNAs that interact with target sequences on messenger RNAs. MiRNAs have been proven to regulate the expression of many genes and play...
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