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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Parkinson’s Pathway Molecular Data Analysis Program, 2022
    Mining for Protein Aberrations in Parkinson’s Disease Using Large-Scale Protein Databases

    Study Rationale: Deficient clearance of misfolded alpha-synuclein aggregates contributes to the pathology of Parkinson’s disease (PD). But broader disturbances in proteostasis—the balanced production...

  • Cellular Phenotyping in Human iPSCS from the PPMI Cohort, 2022
    Simultaneous Profiling of Gene Expression Patterns from Pooled Cell Samples of Large Parkinson’s Disease Cohorts

    Study Rationale: The PPMI study provides a repository of stem cells that can be converted into dopamine-producing neurons and microglia for modeling Parkinson’s disease (PD). Maintaining these cells...

  • Expanding Biological Understanding of Parkinson's Disease, 2022
    Gaining Mechanistic Insights into PINK1 Genetic Variants

    Study Rationale: Mutations in the Parkin and PINK1 genes cause early-onset familial Parkinson's disease (PD). These genes produce enzymes that function together to degrade damaged mitochondria, the...

  • Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022
    Validation of RRx-001 as a Novel Disease-modifying Therapeutic for Parkinson's Disease

    Study Rationale: Our project will test the effectiveness of a new treatment for Parkinson’s disease (PD) called RRx-001. We believe this drug could be beneficial in PD by blocking inflammasome...

  • Target Advancement Program, 2022
    Targeting GPR43 in T-cells as a Potential Treatment for Parkinson’s Disease

    Study Rationale: Parkinson's disease involves the generation of pathogenic proteins in the neurons, which trigger an immune response driven by inflammatory lymphocytes that infiltrate the brain and...

  • Expanding Biological Understanding of Parkinson's Disease, 2022
    Evaluating the Role of Miro1 in Mitochondrial Quality Control in Parkinson’s Disease

    Study Rationale: Growing evidence suggests that dysfunction is linked to Parkinson’s disease (PD). These structures supply cells with energy, but must be eliminated when they become damaged — a...

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