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Funding

Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LEAPS, 2005
    Michael J. Fox Foundation Validation Study

    The role of genetics in PD continues to be a major focus in the field and much of what we know about possible underlying mechanisms of PD cause and pathogenesis has come through studies of genes (e.g...
    Researchers:

    Lorene Nelson, PhD, MS | Haydeh Payami, PhD | John P.A. Ioannidis, MD, PhD | Hideshi Kawakami, MD PhD | Christine Van Broeckhoven , PhD, DSc | Rejko Krüger, MD

    Details
  • Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2005
    Mechanisms of Graft-Induced Dyskinesias in an Animal Model of Parkinson's Disease (Supplemental Funding)

    Our ongoing project has four aims:

    1. To develop a model of graft-induced dyskinesia (GID) in the rat, which will provide a cost-effective tool for studying the mechanisms of this complication;
    2. To...
    Researchers:

    Patrik Brundin, MD, PhD | M. Angela Cenci Nilsson, MD, PhD

    Details
  • The Role of Inflammation in Parkinson's Disease, 2005
    Development of a Dominant-Negative TNF Lentiviral Approach

    Because TNF inhibitors are not believed to cross the blood-brain barrier, an orally administered TNF-based therapy is not currently possible. The Foundation has awarded supplemental funding to drive...
    Researchers:

    Malú G. Tansey, PhD

    Details
  • Community Fast Track, 2005
    Nigrostriatal Dopaminergic Degeneration and Alpha-synuclein Aggregation in Mice with Reduced TrkB Signaling

    Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons and deposition of cytoplasmic protein aggregates termed Lewy bodies (LB) in a brain structure termed substantia...
    Researchers:

    Baoji Xu, PhD

    Details
  • Community Fast Track, 2005
    Pathophysiological Role of PINK1 in Rodent Brain

    Mutations in the PINK1 gene were recently linked to autosomal recessive parkinsonism. However, to date, very little is known about the role of PINK1 in the brain. Our group has ample expertise with...
    Researchers:

    Veerle Baekelandt, PhD | Zeger Debyser, MD, PhD

    Details
  • Community Fast Track, 2005
    Novel Therapeutic Approaches for Parkinson ’s Disease

    Our goal is to develop novel therapeutic agents for the treatment of Parkinson's disease. We will focus on two compounds. One of these blocks the mitochondrial permeability transition (MPT), which is...
    Researchers:

    Myron Flint Beal, MD

    Details
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