The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Therapeutics Development Initiative, 2006PN277: A NEURO- RESTORATIVE, PROTECTIVE PRODUCT FOR PARKINSON’S DISEASE
Acute and chronic neurodegenerative disorders such as Parkinson's disease, stroke, head trauma, spinal cord injury, Huntington's, Alzheimer's and ALS affect millions of people worldwide. Currently...
-
Therapeutics Development Initiative, 2006Develop Engineered Zinc Finger Protein Transcriptional Activators of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene as a Potential Therapy for Parkinson's Disease
Engineered zinc finger protein transcription factors (ZFP TFs) are an emerging class of molecules with the potential for broad therapeutic impact in the treatment of human disease. ZFP TFs function by...
-
Community Fast Track, 2006Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical ModelsThe study of genetic forms of Parkinson’s disease is important for revealing the mechanisms of pathogenesis, and for future therapeutic developments. LRRK2 is the recently identified gene for Park8...
-
Target Validation, 2006Identification of therapeutics that protect against toxins and genes implicated in Parkinson’s disease via the Forkhead-mediated transcription pathway
Loss of dopaminergic neurons is one of the cardinal features of Parkinson’s disease. Medications that can delay or prevent dopaminergic loss could be beneficial in treating PD, but the optimal...
-
Cell Line, 2006Improving the Long-term Survival & Functionality of the Transplanted Human Dopaminergic Neurons Through Space Creation Strategy
Dr. Xuejun Wen was awarded a one-year award in 2004 as part of the MJFF Cell Line II program. Dr. Wen proposed to test a novel biodegradable ‘spacer’ device to improve embryonic stem (ES) cell-derived...
-
Specification, Patterning, and Maintenance of Midbrain Dopam, 2006Generation of Midbrain Dopamine Neurons from Human ES Cells by Forced Expression of Lmx1a
Drs. Ericson and Perlmann have identified two key transcription factors (Lmx1a and Msx1) that regulate early development of dopamine neurons and can induce nearly 90% ‘authentic’ dopamine neurons when...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.