The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2005Neoangiogenesis and Blood-Brain Barrier in L-DOPA-induced Dyskinesia
Fluctuations in brain levels of levodopa play a key role in the production of dyskinesia (abnormal involuntary movements) and motor fluctuations in Parkinson's disease. This project explores the...
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Community Fast Track, 2005A Novel Animal Model to Identify the Contribution of Iron Mismanagement to Neurotoxicity and a-synuclein deposition in Basal Ganglia
Iron in the substantia nigra is an etiological factor in PD. In addition, iron is established as a key determinant in neurotoxin-based models of PD. Iron is critical for cells to interact with oxygen...
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Community Fast Track, 2005Activation of Nrf2 neuroprotective pathways for Parkinson’s disease
Parkinson's disease is characterized by the progressive loss of specific cells of the brain region called substantia nigra that produce the chemical messenger dopamine. The current mainstay therapy is...
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Community Fast Track, 2005Evaluation of the Role of Trace Amine 1 (TA1) Receptor in the Actions of Antiparkinsonian Drugs Using TA1 Receptor Knockout Mice
One potential explanation of unprecedented efficacy of levodopa in the treatment of Parkinson's disease suggests that levodopa itself or its metabolites may affect targets in the brain in addition to...
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Community Fast Track, 2005Role of corticostriatal neurons in provoking the imbalance between the direct and indirect striatal output pathways after dopamingergic degeration
The striatum receives massive excitatory inputs from the cortex and is densely innervated by dopamine. Striatal projection neurons belong either to the direct or indirect pathways. Models of Parkinson...
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Community Fast Track, 2005Pathogenesis of PD in alpha-synuclein cleavage by matrix metalloproteinase-3
A recent finding from our research strongly indicates that matrix metalloproteinase-3 (MMP-3), a protein-cleaving enzyme, plays a pivotal role in degeneration of dopamine neurons in models of...
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Our funding programs support basic, translational and clinical research from academia and industry.