The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Community Fast Track, 2004Dysregulation of Ubiquitylation in Parkinson's Disease
It is now widely accepted that the ability to maintain appropriate levels of proteins is of fundamental importance to the normal function of neurons and other cells. The levels of many proteins are...
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Community Fast Track, 2004Cytoprotective role of ABAD in Parkinson disease
Mitochondrial dysfunction and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the features of Parkinson's disease (PD). We have identified a multifunctional member of the...
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Community Fast Track, 2004Alpha-synuclein and Environmental Exposures: A Study in Humans
The long-term goal of this research is to find the cause or causes of typical, late-onset sporadic Parkinson's disease (PD). To date the search for genetically determined risk factors that could...
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Cell Replacement Therapy, 2004Novel protocols for the differentiation and functional integration of embryonic and neural stem cell-derived dopaminergic neurons in rodent models ofParkinson’s Disease
The properties of stem cells have created the exciting possibility of producing high numbers of virtually any human cell type for cell replacement therapies. However, their implementation in Parkinson...
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Cell Replacement Therapy, 2004Transplanation of Cell-Derived Dopaminergic Neurons Into the Brains of MPTP-treated Pre-clinical Models
Previous work has identified a stromal cell-derived inducing activity (SDIA) in a stromal cell line (PA6 cells) that can induce mouse and primate ES cells to differentiate into mid/hindbrain neurons...
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Cell Line, 2004Improving the Long-term Survival & Functionality of the Transplanted Human Dopaminergic Neurons Through Space Creation Strategy
The ultimate goal of this study is to enhance the long-term viability and functionality of human embryonic stem (hES) cell-derived dopaminergic (DA) neurons for cell therapy in Parkinson's disease. To...
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Our funding programs support basic, translational and clinical research from academia and industry.