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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2022
    Perspective and Consensus on Prevention Planning for Parkinson’s Disease

    Study Rationale: In October 2022, a conference on “Planning for Prevention of Parkinson's: A trial design forum” gathered a broad range of stakeholders interested in preventing Parkinson’s disease (PD...

  • Accelerating the Translation of Parkinson's Disease Therapies, 2022
    Testing Small Molecules that Activate Removal of Cellular Debris for the Treatment of Parkinson’s Disease

    Study Rationale:
    People with Parkinson’s disease (PD) exhibit a diminished ability to remove cellular trash — including old and damaged molecules and organelles — from the brain. This impairment is...

  • Research Grant, 2022
    LEARN-ATMP – Using the Patient Voice to Develop a Framework for Accessible ATMP Trials

    Study Rationale: New therapies for Parkinson’s disease (PD) that involve the use of cells or genes — sometimes called advanced therapy medicinal products (ATMP) — are being developed and tested in...

  • Accelerating the Translation of Parkinson's Disease Therapies, 2022
    Esya PD360: A Multi-parametric Platform for Establishing a Novel Lysosome-based Biomarker and Identifying Therapeutic Interventions for Parkinson’s Disease

    Study Rationale: Lysosomes are sub-cellular compartments responsible for clearing proteins that are prone to aggregation, a process called autophagy. Dysfunctional lysosomes with increased acidity and...

  • Summer 2022 RFP: Accelerating the Translation of Parkinson's Disease Therapies, 2022
    Validation of a Novel Mitochondrial Drug Target for Parkinson’s Disease

    Study Rationale: Mitochondria provide cells with energy, but they also help regulate the flow of large amounts of calcium ions that flood neurons when they are active. In Parkinson’s disease (PD)...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Evaluating an Insulin-degrading Enzyme as a Novel Therapeutic Target for Parkinson’s Disease

    Study Rationale: In Parkinson’s disease (PD), the clumping of the protein alpha-synuclein in the brain causes the death of neurons. Recent studies have shown that the insulin-degrading enzyme (IDE)...

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