The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program - Pre-Clinical, 2026Preclinical Efficacy Studies for CU-13001, a 15-Lipoxygenase Inhibitor for the Treatment of Parkinson’s Disease
Study Rationale:
For over 30 years, scientists have linked lipid oxidation, a type of damage to cellular fats, with Parkinson’s disease. However, the precise cause of this damage...
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Research Grant, 2025Development of a Tau Oligomerization Inhibitor for the Treatment of Parkinson’s Disease
Study Rationale: Tau aggregation is caused by hyperphosphorylation and misfolding of the Tau protein in the brain, leading to cellular dysfunction and neurodegeneration. Preclinical and clinical...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Developing VDAC1 Oligomerization Inhibitor for Treating Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) damages brain cells that control movement, largely due to problems in the cells’ energy factories, called mitochondria. A protein called VDAC1 helps regulate...
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Fall 2025 RFP: Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program-Biomarkers, 2025Use of CapScan as a Non-invasive Tool for Intestinal Fluid Alpha-synuclein and Gut Biomarker Detection in Patients with Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is linked to abnormal clumps of a protein in the body called alpha-synuclein (asyn), which can now be detected in living people using an advanced laboratory...
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T2T Validation - Endolysosomal Targets, 2025Exploring TMEM175 as a Key Target in the Pathogenesis of Parkinson's Disease
Study Rationale: Genetic variants in TMEM175 are amongst the top 5 strongest genetic risk variants in Parkinson’s disease (PD), with one variant increasing risk for the disease, and one variant...
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Research Grant, 2025Alpha-synuclein PET Imaging in Patients
Study Rationale: We developed [11C]SY08 for alpha-synuclein PET imaging. Our early findings in people showed increased brainstem binding and a trend towards increased cortical binding in Parkinson’s...
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Our funding programs support basic, translational and clinical research from academia and industry.