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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Mitochondrial Complex 1 PET Imaging in Parkinson’s Disease

    Study Rationale:
    Methods are needed for imaging early pathological changes in the brain. With such brain imaging, we would be able to determine whether medications are protecting against progression...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Development of a Colony Stimulating Factor 1 Receptor (CSF1R) Radioligand for Imaging Microglia-selective Inflammation

    Study Rationale:
    We have shown that Parkinson’s disease has an underlying neuroinflammatory component that involves microglia, which are inflammatory and immune cells in the brain. We have developed...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Multimodal MR Imaging of the Midbrain for Early Parkinson’s Progression

    Study Rationale:
    Parkinson’s disease (PD) is marked by the loss of dopamine neurons in part of the midbrain, a section toward the base of the brain that serves important functions in movement. In the...

  • Therapeutic Pipeline Program, 2019
    Miro1-targeting Drug Discovery for Parkinson's Disease

    Study Rationale:
    There is mounting evidence for involvement of mitochondrial biology in the pathogenesis of Parkinson’s disease (PD). Alterations in mitochondrial dynamics and distribution have been...

  • Therapeutic Pipeline Program, 2019
    Screening for Precision Parkin Activators

    Study Rationale:
    Defects in the protein parkin cause the loss of nerve cells in the brain and are responsible for many cases of young-onset Parkinson's disease that develops before 50 years of age. We...

  • Research Grant, 2019
    Patient Reports on Cannabis Use in Parkinson's Disease

    Study Rationale:
    Medical marijuana (cannabis) is now legal in 47 states, and recreational use is legal in nine. Interest in cannabis for treating Parkinson’s disease (PD) is rapidly increasing...

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