The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Astrocyte Biology in Parkinson's Disease, 2019How Astrocytes Cause Neuronal Loss by Reacting to Alpha-synuclein
Study Rationale:
Research in Parkinson’s disease has largely focused on events that occur within neurons that are lost in disease. However far more abundant than neurons in the human brain are a type... -
Astrocyte Biology in Parkinson's Disease, 2019Exploring Proteins associated with Alpha-synuclein in Astrocytes at Different Stages of Parkinson’s Disease
Study Rationale:
In addition to neurons, astrocytes are the other major cell type that have increased alpha-synuclein in Parkinson’s disease (PD). In fact, more astrocytes have increased alpha... -
Improved Biomarkers and Clinical Outcome Measures, 2019Mitochondrial Complex 1 PET Imaging in Parkinson’s Disease
Study Rationale:
Methods are needed for imaging early pathological changes in the brain. With such brain imaging, we would be able to determine whether medications are protecting against progression... -
Improved Biomarkers and Clinical Outcome Measures, 2019Development of a Colony Stimulating Factor 1 Receptor (CSF1R) Radioligand for Imaging Microglia-selective Inflammation
Study Rationale:
We have shown that Parkinson’s disease has an underlying neuroinflammatory component that involves microglia, which are inflammatory and immune cells in the brain. We have developed... -
Improved Biomarkers and Clinical Outcome Measures, 2019Multimodal MR Imaging of the Midbrain for Early Parkinson’s Progression
Study Rationale:
Parkinson’s disease (PD) is marked by the loss of dopamine neurons in part of the midbrain, a section toward the base of the brain that serves important functions in movement. In the... -
Therapeutic Pipeline Program, 2019Miro1-targeting Drug Discovery for Parkinson's Disease
Study Rationale:
There is mounting evidence for involvement of mitochondrial biology in the pathogenesis of Parkinson’s disease (PD). Alterations in mitochondrial dynamics and distribution have been...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.