The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2019Mechanistic Characterization of the PINK1-amplifying Compound MTK-458
Study Rationale:
Loss-of-function mutations in components of the PINK1/PRKN pathway lead to early onset Parkinson’s disease. Previous work by our company has shown that our compounds can amplify the... -
Research Grant, 2019Supplement: Investigation of PINK1-dependent Phosphorylation of Rab GTPases
Promising Outcomes of Original Grant:
We were trying to understand how the PINK1 gene targets a set of proteins known as Rab GTPases through protein modification known as phosphorylation. The... -
Research Grant, 2019PPM1H Activators for the Treatment of Parkinson’s Disease
Study Rationale:
Although Parkinson’s disease (PD) causes are in most cases unknown (idiopathic) some cases are linked to a person’s genetics. Leucine-rich repeat kinase 2 (LRRK2) is a very important... -
Epidemiological Parkinson's Risk Modifiers, 2019Study in Finnish Population to Identify Therapies with Repurposing Potential for Parkinson’s Disease
Study Rationale:
Effective treatments for slowing the progression of Parkinson’s disease are urgently needed. Searching for possible treatments among drugs already used for other indications is a... -
Therapeutic Pipeline Program, 2019Biomaterial-enhanced Cellular Brain Repair for Parkinson's Disease
Study Rationale:
One promising approach for the treatment of Parkinson’s is to replace the cells that have died in the disease through transplantation of healthy cells into the brain. However, this... -
Target Advancement Program, 2019Connexins as a New Therapeutic Target to Impede Spreading of Alpha-synuclein Pathology
Study Rationale:
Direct cellular connectivity has recently been implicated in the transfer of alpha-synuclein pathology associated with Parkinson’s disease. The gap junction proteins known as...
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Our funding programs support basic, translational and clinical research from academia and industry.