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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Freezing of Gait, 2024
    Adaptive Cortical Neuromodulation Using a Brain-machine Interface to Treat Freezing of Gait in Parkinson’s Disease

    Study Rationale: Difficulties with walking can have significant impacts on the quality of life of people with Parkinson’s (PwP). One of the most serious is freezing of gait (FOG), which are brief but...

  • Freezing of Gait, 2024
    TURN-IT: A Novel Intervention to Improve Turning in People with PD and Freezing of Gait

    Study Rationale: Turning is a critical aspect of mobility for people with PD that, in some individuals, can precipitate freezing of gait. We recently developed a turn-specific intervention for people...

  • Freezing of Gait, 2024
    Use of Soft Robotic Apparel to Prevent Freezing of Gait in Parkinson’s Disease

    Study Rationale: Freezing of gait (FoG) is a disabling walking problem that leads to loss of mobility, falling and poor quality of life in many people with Parkinson’s disease (PD). People with FoG...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Use of an Angiotensin-(1-7) Glycopeptide, to Treat Dementia in Parkinson's Disease

    Study Rationale: Peptide-based drugs are attractive candidates for treating the cognitive decline associated with Parkinson’s disease (PD) because they demonstrate a robust safety profile and an...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Development of Selective Ion Channel Inhibitors as a Disease-modifying Therapy for Parkinson’s Disease

    Study Rationale: Our aim is to develop an oral medication that will protect the dopamine neurons whose loss is thought to be the cause Parkinson’s disease (PD). Evidence suggests that excessive levels...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Examining the Effects of MTX325 on Mitochondrial Quality Control and the Prevention of Parkinson’s Disease Progression

    Study Rationale: Mitochondria generate the energy needed for cells to work properly, and impaired mitochondrial function has been linked to the loss of dopamine neurons in multiple forms of Parkinson...

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