To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
iMCI-PARK Mouse*
Mouse Model
Inducible MCI-PARK (iMCI-PARK) mice, based on the ESR-NDUFS2 strain described by Fernández-Agüera, 2015, were generated by crossing mice carrying a floxed allele of mouse Ndufs2 with mice that broadly express tamoxifen-inducible cre recombinase (Tg(CAG-cre/Esr1*)5Amc that result in a conditional, body-wide knock-out of Ndufs2 following tamoxifen induction. Model was originally designed by deleting Ndufs2 only from dopaminergic neurons by D. James Surmeier at Northwestern University and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038571
LRRK2 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout LRRK2 on a Sprague Dawley rat background.
Estimated Availability: Early 2026
Parkin KO x Polg Mutator Mouse*
Mouse Model
Parkin KO x Polg Mutator mice were generated by crossing PolgAD257A mutant mice, lacking mitochondria polymerase proofreading function, with Parkin KO mice. Model was designed by Kelly Stauch and Howard Fox at University of Nebraska Medical Center and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036670
PINK1 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout PINK1 on a Sprague Dawley rat background.
Estimated Availability: Late 2025
Parkin KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout Parkin on a Sprague Dawley rat background.
Estimated Availability: Late 2025
SNCA Triplication iPSC line set*
Human iPS Cell
iPSC line derived from a patient with the SNCA triplication mutation. Corrected lines with normal SNCA expression levels and TdTomato reporter KI versions of the lines will also be available. These lines were generated and kindly deposited by Vik Khurana into the MJFF Sponsored Tools Program.
Expected Availability: Late 2025
Ubiquitin pS65 Phosphospecific Antibody (Ms ELISA)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of mouse ubiquitin. Suitable for ELISA applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunoblot, immunocytochemistry, and ELISA applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
Ubiquitin pS65 Phosphospecific Antibody (IHC)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunohistochemistry applications. Detailed characterization data is published in Watzlawik et al, Autophagy 2024.
AAV2/5-CBh-eBFP
Viral Vector
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic