To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
Parkin KO Rat*
Rat Model
Homozygous rat knockout of Parkin in the Long Evans Hooded rat strain. RRID:RGD_7241052
DJ-1 KO Rat*
Rat Model
Homozygous rat knockout of DJ-1 created by 8 base pair deletion plus 1 base pair substitution in Exon 5 in the Long Evans Hooded rat strain. RRID:RGD_7241048
ASAH1 Knockout A549 Cell Line
Immortalized Cell
A549 cell with homozygous knockout of ASAH1.
Estimated Availability: Early 2025
Human GCase Antibody
Antibody
Rabbit monoclonal antibody directed against human GCase for immunostaining applications. Antibody generation failed.
PPMI iPSCs
Human iPS Cell
Induced pluripotent stem cell (iPSC) lines are available through the PPMI repository. The repository includes lines from control, idiopathic PD, genetic PD (LRRK2, GBA, SNCA), genetic unaffected carriers (LRRK2, LRRK2/GBA, GBA, SNCA), and prodromal patients. Gene-revertant controls are available for select lines. An inventory of available lines can be found here: https://zenodo.org/records/10607589
RILPL1 Antibody
Antibody
Rabbit monoclonal antibody directed against total rodent/human RILPL1 protein. Suitable for immunoblot, immunoprecipitation, and immunocytochemistry experiments.
SNCA Multiplication iPSC Lines*
Human iPS Cell
Isogenic iPSC lines harboring a triplication , duplication, single copy, or KO of the SNCA gene derived from a patient with the triplication mutation. These lines were generated and kindly deposited by Birgitt Schuele at Stanford University into the MJFF Sponsored Tools Program.
Total DJ-1 Antibody
Antibody
Mouse monoclonal antibody directed against full length DJ-1. Ideal for use in immunoblotting or immunoassays.
Mouse Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of mouse monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_89075
Rab 12 Antibody (WB)
Antibody
Rabbit monoclonal antibody directed against human/mouse Rab 12. Suitable for use in western blotting.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic