To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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p62 pT138 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine 138 of the p62 protein. Suitable for immunoblotting applications.
OMP25 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse OMP25 for immunoprecipitation of endogenous mitochondria.
Estimated Availability: Late 2025
Oligomeric Alpha-Synuclein Protein*
Protein
Stable oligomeric aggregates of alpha-synuclein protein. Intended for use in biochemical assays (not intended for use in the pre-formed fibril model).
Human Alpha-Synuclein A53T Mouse*
Mouse Model
Transgenic mice expressing the A53T missense mutant form of human alpha-synuclein under the control of the murine prion promoter. Model was generated and deposited by Michael Lee at University of Minnesota through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006823
iPLA2beta Knockout Mouse*
Mouse Model
Mice carrying a Pla2g6 mutation resulting replacement of exon 2 by a NEO cassette. Model was generated and deposited by Zemin Yao at University of Ottawa through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:023542
Parkin/PINK1 Double KO Rat
Rat Model
Knockout of Parkin and PINK1 in the Long Evans Hooded rat strain.
Humanized SNCA Mouse
Mouse Model
Mouse expressing the full human SNCA gene (including promoter, introns, and regulatory elements) without endogenous murine SNCA. Please note: MJFF was not successful in generating this line after multiple attempts. Alternative BAC human alpha-synuclein mouse lines are available at JAX.
Alpha-Synuclein Filament Protein
Protein
Full-Length human alpha-synuclein protein expressed in vitro and manipulated to form alpha-synuclein filaments.
Note: This filament version of alpha-synuclein was used as antigen for the MJF-14 conformation-specific rabbit monoclonal alpha-synuclein filament-specific antibody which is available at Abcam. This protein is not intended for use as a pre-formed fibril for seeding alpha-synuclein pathology in vivo or in vitro. For protein to use in an alpha-synuclein pre-formed fibril model please use the "Human alpha-synuclein monomer protein for making pre-formed fibrils" available from Proteos.
Alpha-Synuclein Monomer Protein for PMCA/RT-QuIC Assays
Protein
Recombinant human alpha-synuclein monomeric protein designed to serve as substrate in PMCA/RT-QuIC assays.
Estimated Availability: Late 2025
Generated as part of the Industry Tools Consortium.
DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
Protein
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic