To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
Full Length pS129 Alpha-Synuclein Protein
Protein
Phospho-S129 Alpha Synuclein semi-synthetic phosphomimetic protein generated by native chemical ligation of a recombinant peptide produced from E. coli and a synthtic peptide
Floxed S69R Rab32 Mouse
Mouse Model
Mouse expressing the S69R point mutation in the mouse Rab32 gene (corresponds to the S71R mutation in human Rab32). LoxP sites flank the Rab32 gene to enable conditional Cre-mediated knockout.
Estimated Availability: Early 2026
Floxed Parkin Mouse*
Mouse Model
Mice with loxP sites flanking Parkin exon 4 for conditional knockout using Cre-expressing viral vectors. Model was generated and deposited by Dr Ted Dawson at Johns Hopkins University through the MJFF Sponsored Tools Program.
FLAG LRRK2 G2019S Mouse*
Mouse Model
Mice expressing FLAG-LRRK2-G2019S transgene directed by the endogenous LRRK2 promoter/enhancer regions on the BAC transgene. Model was generated and deposited by Zhenyu Yue at Mount Sinai School of Medicine through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:012467
EIF4G1 R1207H Mouse
Mouse Model
Mice expressing the R1207H mutant form of EIF4G1. RRID:IMSR_JAX:021827
Eif4g1 KO
Mouse Model
Mice carrying a targeted Eif4g1 mutation in which exons 24 through 28 are deleted. RRID:IMSR_JAX:024521
DOX-Inducible iPSC-Derived Dopamine Neuron
Human iPS Cell
Inducible iPSC line in which addition of doxicycline to the media stimulates differentiation into dopamine neurons with 90% purity in a matter of days.
Estimated Availability: Mid 2026
DNAJ26 Plasmids
DNA Plasmids
DNA Plasmids encoding various DNAJ26 cDNA inserts
DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
Protein
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
Protein
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic