To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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SNCA Floxed Mouse*
Mouse Model
Mice with loxP sites flanking SNCA exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:025636
SNCA Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in SNCA, including heterozygous and homozygous A53T, A30P, E46K, and R219Q mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).
SMPD1 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in SMPD1, including heterozygous and homozygous L262Rfs*3, heterozygous and homozygous Q294K, and homozygous knockout mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP). Estimated Availability: Q1 2026.
SCD5 Antibody
Antibody
Rabbit monoclonal antibody directed against human SCD5 for immunoblotting and immunostaining applications.
Estimated Availability: Early 2025
SCARB2 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in SCARB2, including heterozygous and homozygous R424, heterozygous and homozygous W146Sfs*15, and homozygous knockout mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP). Estimated Availability: Q1 2026.
S69R Rab32 KI Mouse
Mouse Model
CRISPR/Cas9 genome targeting strategy to knockin S69R point mutation in the endogenous mouse Rab32 gene (corresponds to the S71R mutation in human Rab32).
Estimated Availability: Early 2025
ROSA26 LRRK2 R1441C Mouse*
Mouse Model
Mice carrying human LRRK2 R144C mutation inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:026293
ROSA SNCA Knockout Mouse*
Mouse Model
Mice carrying SNCA knockout allele and Gt(ROSA)26Sor Cre reporter allele. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028560
ROSA LRRK2 R1441C Mouse*
Mouse Model
Transgenic mice with human LRRK2 R1441C inserted into the endogenous Gt(ROSA)26Sor locus. Model was generated and deposited by Darren Moore at Van Andel Research Institute through the MJFF Sponsored Tools Program (available through cryorecovery).
RILPL2 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse RILPL2 for immunoblotting and immunostaining applications.
Estimated Availability: Early 2025
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic