Dr. Xuemei Huang is a board-certified research neurologist whose clinical practice and scholarly concentrations are focused on Parkinson’s disease (PD) and related neurodegenerative disorders. She has a strong interest in translational neuroscience and her major focus is the use of novel imaging approaches and designs to examine the neural circuits (including basal ganglia and cerebellum) underlying PD signs and symptoms, and the development of imaging biomarkers for PD and related disorders. During her early training, Dr. Huang recognized that longitudinal studies could be extraordinarily powerful in understanding structural changes that occur as PD progresses. This realization led to her first NIH R01 research grant (Structural MRI markers for PD) and a subsequent U01 grant (Multimodal MRI markers for PD progression). The U01 project collected the biofluids and data that will be used for the current proposal.