The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2015Lysosomal Enzyme Activity and GBA1 Genotyping in Parkinson’s Disease
Study Rationale:
The dysfunction of the systems responsible for the clearance of the protein alpha-synuclein plays a major role in Parkinson’s disease (PD). The lysosome is an... -
Therapeutic Pipeline Program, 2015Utilization of Aptamers to Prevent Protein Aggregation in Parkinson’s Disease
Objective/Rationale:
The abnormal aggregation of a protein known as alpha-synuclein appears to play a critical role in Parkinson's disease. This project will explore a new type of... -
Target Validation, 2015Targeting the NLRP3 Inflammasome in Models of Parkinson's Disease
Objective/Rationale:
Chronic inflammation within the brain is emerging as a possible driver in the progression of Parkinson’s disease (PD). Inflammasomes are protein complexes that... -
Target Validation, 2015Comparison of Nedd4 and GBA for Improving Protein Handling and Reducing Alpha-synucleinopathy
Study Rationale:
Lysosomes are key intra-cellular organelles involved in the degradation of proteins including alpha-synuclein. Lysosomal protein degradation systems fail in... -
Target Validation, 2015Pathogenetic Mechanisms in Early-onset Parkinsonism Resulting from a Mutation in the Synaptojanin 1 Protein
Study Rationale:
Several proteins encoded by Parkinson’s disease (PD) genes have been linked to vesicular traffic (movement of molecules) at synapses (junctions between neurons)... -
Target Validation, 2015Validation of the Rip Kinase Pathway as a Therapeutic Target in Parkinson's Disease
Study Rationale:
A genetic connection has been shown over the past few years between Parkinson’s and Gaucher’s diseases, such that people with genetic mutations that cause Gaucher’s disease have a...
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Our funding programs support basic, translational and clinical research from academia and industry.