The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
Study Rationale: The aggregation of a structurally abnormal form of the protein alpha-synuclein appears to be responsible for the initiation and progression of Parkinson’s disease (PD). In previous...
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Alpha-synuclein Seed Amplification Assay Program, 2022Development of a Reliable Diagnostic Test for Parkinson’s Disease Using Patient Blood Samples
Study Rationale: Although diagnosis of Parkinson’s disease (PD) is crucial for the success of treatment, especially in the early stages, there are still no biomarkers available for use as a reliable...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Inhibiting Lrrk2 Specifically in the Brain
Study Rationale: Neurodegenerative disorders such as Parkinson’s disease (PD) affect the brain. Some of the drugs designed to treat PD have unwanted side effects in the rest of the body. To minimize...
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Phase 1b Trial to Assess the Safety and Efficacy of Dopamine Cell Transplants in Parkinson’s Disease Linked to Mutations in Parkin
Study Rationale: We have shown that although cell transplants are able to produce dopamine and improve motor problems in some individuals with Parkinson’s disease (PD), differences in the quality of...
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Diversity, Equity and Inclusivity in Parkinson's research, 2022Assessing the Awareness, Perception, Diagnosis, and Treatment of Parkinson’s Disease in Africa
Study Rationale: Parkinson’s disease (PD) is little known in most parts of Africa and its symptoms are often ascribed to normal aging or to an unknown disorder. Most health care facilities lack the...
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Fall 2021 RFP: Outcome Measures, 2022Use of Integrated, Multi-omic Data Analysis for Screening and Treatment of Parkinson’s Disease
Study Rationale: Current diagnostic criteria and treatment options are designed for the “average” person with Parkinson’s disease (PD). This one-size-fits-all approach ignores the huge biological and...
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Our funding programs support basic, translational and clinical research from academia and industry.