The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2017Protein Homeostasis and the Ubiquitination Pathway in Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) involves accumulation of toxic proteins in cells in specific areas of the brain. These cells normally have protective mechanisms to remove these toxic... -
Target Advancement Program, 2016Assessing the PINK1 Pathway in Parkinson
Study Rationale:
Rare mutations in the PINK1 gene cause familial (inherited) Parkinson's disease (PD). However, it is not known if PINK1 contributes to the development of idiopathic (no known cause) PD... -
Research Grant, 2016Investigation of LRRK2 as a Regulator of Dendritic Cell Function
Promising Outcomes of Original Grant:
Myeloid cells (white blood cells) of the immune system include monocytes, neutrophils and dendritic cells found in circulation, as well as microglia (immune system... -
Research Grant, 2016Chemical Knockdown of LRRK2 by Small Molecule PROTACS
Study Rationale:
LRRK2 is a protein kinase that appears to be a key driver of some forms of Parkinson's disease (PD). Several potent, selective, brain-penetrant LRRK2 kinase inhibitors have been...
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Target Advancement Program, 2016Using LRRK2 Computer Simulations to Identify Therapeutic Targets for Parkinson's Disease
Study Rationale:
LRRK2 interacts with over 60 proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the cell), neurites (cellular... -
Target Advancement Program, 2016Targeting the Cell's Energy System in Parkinson's Disease
Study Rationale:
Mitochondria, cellular power plants, malfunction in Parkinson's disease (PD) and with advanced age. Aging and PD cause changes in communication between mitochondria and the rest of...
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Our funding programs support basic, translational and clinical research from academia and industry.