The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2022Assessment of Alpha-synuclein Aggregation Inhibitor ASN121151 as a Potential New Treatment for Parkinson’s Disease
Study Rationale: Genetic defects in the gene encoding alpha-synuclein cause the protein to aggregate in the brains of people with a familial form of Parkinson’s disease (PD). We have developed a novel...
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Alpha-synuclein Seed Amplification Assay Program, 2022Maximizing the Sensitivity of Seed Amplification Assays Used to Detect Alpha-synuclein Aggregates
Study Rationale: One characteristic of Parkinson’s disease (PD) is the aggregation of proteins such as alpha-synuclein in the brain. To diagnose PD, it is important to be able to detect such...
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Diversity, Equity and Inclusivity in Parkinson's research, 2022Overcoming Inequity in the Treatment of Parkinson’s Disease: Recognizing and Caring for Underserved Communities in Brazil
Study Rationale: Brazil has enormous economic and social inequalities. Pesticides, heavy metals and other pollutants can contribute to the development of degenerative conditions such as Parkinson's...
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2022: Accelerated Therapeutics Program, 2022Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies
Study Rationale: LBT-3627 is a disease-modifying therapeutic candidate that has been shown to reduce brain inflammation and immune imbalance in preclinical models of Parkinson's disease (PD). A recent...
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Research Grant, 2022Developing a Method for Detecting Alpha-synuclein in the Acidic Cell Compartments in Which It Accumulates
Study Rationale: The protein alpha-synuclein forms harmful clusters or aggregates that can kill neurons in the brains of people with Parkinson’s disease (PD). Neurons attempt to eliminate these clumps...
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Fall 2021 RFP: Expanding Biological Understanding of PD, 2022Identifying a Molecular Signature of DNA Damage in the Blood Cells of People with Parkinson’s Disease
Study Rationale: The instructions needed to govern the function of living things are stored in their cells’ DNA. In cell types that divide, such as blood or skin, DNA checked for damage and repaired...
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Our funding programs support basic, translational and clinical research from academia and industry.