The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Allosteric Small Molecule Therapies for Treating GBA1-PD
Study Rationale: Some people with Parkinson’s disease (PD) have a change, or mutation, in a gene called GBA1. This gene makes an important enzyme called GCase, which helps keep brain cells healthy...
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Research Grant, 2025Characterization of Research Antibodies for Parkinson’s Community-nominated Targets
Study Rationale: Antibodies are essential for detecting proteins, but nearly 50% of commercial antibodies fail to work reliably—like a GPS that’s only right half the time. In Parkinson’s research...
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Circuits & Cellular Targets for PD’s Symptoms, 2025Role of B2*-Nicotinic Receptors in Parkinson’s Disease Related Circuits and Symptoms
Study Rationale: One pathological hallmark of Parkinson’s disease (PD) is the degeneration of dopamine neurons innervating the striatum. Dopamine loss is associated with several adaptive changes in...
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Parkinson’s Disease Therapeutics Pipeline Program, 2025Assessing Pre-clinical Efficacy of Brain-penetrant TRPML1 Agonists to Treat Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated alpha-synuclein inside neurons in the brain. This may either arise from, or be exacerbated by...
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Research Grant, 2025Phenotypic and Construct Validity of Pink1-/- in Pre-clinical Models for Pre-clinical Parkinson’s Research
Study Rationale: Parkinson’s disease is a common neurodegenerative disorder that is usually diagnosed in people between 60 and 65 years old, but it likely starts about 20 years earlier. During this...
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MRI Biomarkers Program, 2025Evaluation of Neuromelanin-sensitive, Quantitative Susceptibility Mapping and Free Water Imaging as Biomarkers of Nigral Dopaminergic Dysfunction
Study Rationale: This project seeks to validate three magnetic resonance imaging biomarkers capable of detecting and monitoring the degeneration of neurons in the substantia nigra in Parkinson’s...
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Our funding programs support basic, translational and clinical research from academia and industry.