The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Characterizing Region-specific Lipid Profiles in Parkinson’s Disease and Gaucher Disease
Study Rationale: Mutations in the GBA1 gene, which encodes glucocerebrocidase (GCase), is the most prevalent risk factor for Parkinson’s disease (PD). The resulting deficit in GCase activity leads to...
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Therapeutic Pipeline Program, 2023Developing A Small-Molecule Activator of AMPK for the Treatment of Parkinson’s Disease
Study Rationale: Overwhelming evidence indicates that mitochondrial dysfunction contributes to the development of Parkinson’s disease (PD). We discovered that drugs that activate the enzyme AMPK...
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Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2023Implementation and Validation of Lysosome-specific Tests of GCase Activity in Cell Lines and Human Peripheral Blood
Study Rationale: Glucocerebrosidase (GCase) is an enzyme that is linked to Parkinson’s disease (PD) and is a high value target for disease-modifying treatments. Developing robust methods for...
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Translational Pipeline Program, 2023Targeting Activation of Microglia and Recruitment of Inflammatory Monocytes as a Therapeutic Approach for Parkinson’s Disease
Study Rationale: Inflammation in the brain promotes neurodegeneration and drives the progression of Parkinson’s disease (PD), suggesting that controlling neuroinflammation could provide an important...
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Research Grant, 2023Characterizing the Immune Cells Present in the Blood and Cerebrospinal Fluid of People with Parkinson's Disease Associated with Mutations in LRRK2
Study Rationale: Several studies have demonstrated that people with Parkinson’s disease (PD) have an altered frequency of immune cells in the blood. In addition, immune cells that normally patrol the...
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Translational Pipeline Program, 2023Identifying Small Molecule Inducers of Autophagy and Lysosomes
Study Rationale: Neurons keep themselves healthy and free of damaged cellular materials using an internal garbage collection system called autophagy and internal recycling centers called lysosomes...
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Our funding programs support basic, translational and clinical research from academia and industry.