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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024
    (SUPPLMENT) Evaluating the Neuroprotective Factor REST as a Target for Parkinson’s Disease

    Study Rationale: Studies have shown that a regulatory factor called REST could promote the survival of neurons in neurodegenerative conditions. This factor is produced in greater quantities with age...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Development of Brain-penetrant TrkB Agonist Antibody for Parkinson’s Disease

    Study Rationale: Parkinson's disease (PD) is characterized by the death of dopamine neurons, which control movement. We have generated a novel therapeutic agent — an antibody that activates a receptor...

  • Research Grant, 2024
    Quantification of Three Previously Identified Biomarkers of Progression in Stage 2/3 of Parkinson’s Disease

    Study Rationale: Early indicators for Parkinson’s disease (PD), so-called biomarkers, are needed to identify subjects at risk during the earliest, prodromal stages of disease and to support clinical...

  • Research Grant, 2024
    Funding Support 2024-2026 for Critical Path Clinical Outcome Assessment Experts

    Study Rationale: To evaluate treatments in ways that are meaningful to people with Parkinson’s disease (PD), we need to identify measurements that reflect how people with early PD function and feel...

  • Parkinson’s Disease Therapeutics Pipeline Program, 2024
    Investigating Oxygen Limitation (Hypoxia) as a Novel Treatment for Parkinson’s Disease

    Study Rationale: Non-pharmacological interventions can benefit human health, and anecdotal evidence suggest that people with Parkinson’s disease (PD) show fewer symptoms when traveling at high...

  • Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024
    Enhancing Removal of Damaged Mitochondria in Neurons by Inhibiting the Enzyme Usp8

    Study Rationale: Parkinson’s disease (PD) has long been associated with mitochondrial dysfunction. Perturbation of these subcellular structures can lead to the release of reactive oxygen species (ROS)...

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