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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2016
    Therapeutic Effects of XPro1595 on Motor and Non-motor Outcomes in a Pre-clinical Model of Parkinson's disease

    Study Rationale:
    Studies funded under the 2012 TDI award revealed that peripheral administration of XPro1595 in the 6-OHDA (neurotoxin) pre-clinical model afforded significant neuroprotection against...

  • Improved Biomarkers and Clinical Outcome Measures, 2016
    Defining a Parkinson's Disease-specific Breath Fingerprint of Inflammatory and Neurodegenerative Processes

    Study Rationale:
    Breath analysis has the potential to be a powerful non-invasive screening tool to help a clinician determine the need for additional tests, a tool for routine interval screening of...

  • Research Grant, 2016
    LRRK2 Function in Immunity

    Study Rationale:
    LRRK2 is expressed in immune cells but its function in these cells is unknown. It is also not known whether mutations (such as G2019S) in LRRK2 that cause familial (inherited)...

  • LRRK2 Therapeutic and Safety Initiative, 2016
    Evaluation of LRRK2 Inhibition in a Pre-clinical Model of Parkinson's Disease

    Study Rationale:

    The most common genetic cause of Parkinson's disease (PD) is mutations in the LRRK2 gene. Variations in the LRRK2 gene are associated with non-genetic PD as well. New drugs are being...

  • Improved Biomarkers and Clinical Outcome Measures, 2016
    Identification of Tear Biomarkers for Individuals with Parkinson's Disease

    Study Rationale:
    Prior to the appearance of classic movement abnormalities like tremor and slowness, those with Parkinson's suffer from non-motor symptoms, such as altered function of the...

  • Research Grant, 2016
    Study of Alpha-synuclein in the Dorsal Neostriatum

    Promising Outcomes of Original Grant:
    In February 2013, Luk et al. published in Science that administration of synthetic alpha-synuclein into pre-formed fibrils in pre-clinical models was sufficient to...

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Our funding programs support basic, translational and clinical research from academia and industry.

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