The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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ASAP CRN Competitive Renewal Opportunity, 2024Determining the Role of Proteins Associated with Parkinson’s Disease in T cell-Mediated Destruction of Dopamine Neurons
Study Rationale: Before Parkinson's disease (PD) manifests its characteristic symptoms, the pathological process has been underway for years. Although the initial trigger remains uncertain, we have...
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ASAP CRN Competitive Renewal Opportunity, 2024Identifying Mechanisms that Overwhelm Protein and Organelle Quality Control in Parkinson’s Disease
Study Rationale: Abnormal protein aggregation and prion-like aggregate spreading are hallmarks of the degenerative cascades of sporadic and familial Parkinson’s disease (PD). These toxic aggregates...
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ASAP CRN Competitive Renewal Opportunity, 2024IMPACT-PD: Implications of Polyamine and Glucosylceramide Transport in Parkinson’s Disease
Study Rationale: Mutations in the genes ATP13A2, GBA1 and ATP10B trigger Parkinson’s disease (PD) and cause dysfunction of lysosomes, the recycling compartments of the cell. These genes regulate the...
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ASAP CRN Competitive Renewal Opportunity, 2024Studying the Pathogenesis of Parkinson’s Disease Via Single-cell Analysis of Human Brain and Gut Cells: A Basis for Clinical Translation
Study Rationale: More than 100 regions of the chromosomes that we inherit from our parents show differences in DNA sequence between people with and without Parkinson’s disease (PD). Furthermore, as we...
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ASAP CRN Competitive Renewal Opportunity, 2024Examining the Mechanisms of Mitochondrial Damage Control by PINK1 and Parkin
Study Rationale: Mutations in PINK1 and Parkin genes underlie some forms of Parkinson’s disease (PD). The protein products of these genes are responsible for the maintenance and degradation of...
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ASAP CRN Competitive Renewal Opportunity, 2024Circuit Mechanisms for Dopamine Neuron Vulnerability and Resilience in Parkinson’s Disease
Study Rationale: Dopamine neurons are particularly vulnerable to death in Parkinson’s disease (PD), and their loss is one of the main causes of movement problems in people with PD. Dopamine neurons...
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Our funding programs support basic, translational and clinical research from academia and industry.