Funded Studies

Study Rationale: More than 100 regions of the chromosomes that we inherit from our parents show differences in DNA sequence between people with and without Parkinson’s disease (PD). Furthermore, as we...

Study Rationale: Mutations in PINK1 and Parkin genes underlie some forms of Parkinson’s disease (PD). The protein products of these genes are responsible for the maintenance and degradation of...

Study Rationale: Dopamine neurons are particularly vulnerable to death in Parkinson’s disease (PD), and their loss is one of the main causes of movement problems in people with PD. Dopamine neurons...

Study Rationale: Parkinson’s disease (PD) begins decades before it compromises an individual’s ability to move about in the world and sleep through the night. Understanding how the dysfunction of...

Study Rationale: Although thousands of DNA variants are linked to Parkinson’s disease (PD), their exact functions are unknown. These variants are in the “dark matter” of our genome and do not lead to...

Study Rationale: Activity changes in nerve cells in the brain’s cerebral cortex are central to Parkinson’s disease (PD). However, which specific cell types are affected, and how and when their...