The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2021Wireless “Nanoelectrodes” as a Minimally Invasive Alternative to Conventional Deep Brain Stimulation
Study Rationale: Deep Brain Stimulation (DBS) has been used to ease motor symptoms in people with Parkinson’s disease (PD). This approach requires a surgical procedure to implant electrodes into the...
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Research Grant, 2021Hidden Sorrows of Covid-19: Impact of Stress on Parkinson’s Disease Progression
Study Rationale: People living with Parkinson’s disease (PD) are very sensitive to stress, which worsens motor symptoms (such as tremor) and leads to anxiety and depression. Studies in animals suggest...
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Target Advancement Program, 2021Exploring How a Chemical Produced by Intestinal Microbes Contributes to the Pathology and Progression of Parkinson's Disease
Study Rationale: Imbalances in the bacteria that inhabit the gut have been linked to the onset and progression of Parkinson’s disease (PD). However, the mechanisms by which an altered microbiome can...
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Expanding Biological Understanding of PD, 2021Dissecting the Role of GBA1 and LRRK2 in Regulating the Formation of Lewy Bodies
Study Rationale: A key hallmark of Parkinson’s disease (PD) is the accumulation of alpha-synuclein aggregates inside neurons. These aggregates are known as Lewy bodies (LBs). Although mutations in...
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Aligning Science Across Parkinson's, 2021Redefining Parkinson’s Disease Pathophysiology Mechanisms in the Context of Heterogeneous Substantia Nigra Neuron Subtypes
Study Rationale:
The motor symptoms of Parkinson's disease (PD) result from the degeneration of the dopamine producing neurons in a brain area called the substantia nigra pars compacta (SNc). Recent... -
Aligning Science Across Parkinson's, 2021Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease
Study Rationale:
Many people with Parkinson’s disease develop untreatable cognitive symptoms, including problems with attention, decision-making, and dementia at late stages of the disease, due to...
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Our funding programs support basic, translational and clinical research from academia and industry.