The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2018Studying Measures of LRRK2 Activation and Lysosomal Dysfunction in Parkinson's Disease
Study Rationale:
As new, targeted therapies for Parkinson's disease (PD) enter clinical trials, biomarkers -- objective measures of disease --become increasingly important as tools for matching people... -
Research Grant, 2018Developing New Drugs that Deactivate Deubiquitinase Proteins for the Treatment of Parkinson's Disease
Promising Outcomes of Original Grant:
In our past studies, we aimed to identify small molecule inhibitors of proteins called deubiquitinases (DUBs), i.e., chemicals that makes DUBs unable to perform... -
Improved Biomarkers and Clinical Outcome Measures, 2018Expansion of Studies to Develop Tear Biomarkers of Parkinson's Disease
Promising Outcomes of Original Grant:
We previously explored the hypothesis that changes in tear protein content could represent a biomarker -- objective measure -- of Parkinson's disease (PD). Among... -
Research Grant, 2018Charting a Path to Success for Clinical Trials in Patients with Inherited, GBA-linked Parkinson's Disease: PPMI Supplement
Promising Outcomes of Original Grant:
The original study is ongoing.Objectives for Supplemental Investigation:
We aim to determine whether fatty molecules called sphingolipids can serve as biomarkers --... -
Alpha-Synuclein Biology and Therapies, 2018Sugars Cause Alpha-Synuclein to Form Less-Toxic Clumps
Study Rationale:
Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). Chemicals that stick to alpha-synuclein make it toxic to brain cells. Sugar-like... -
Research Grant, 2018Improving Existing LRRK2 Tests with Novel Reagents
Promising Outcomes of Original Grant:
The goal of our original study was to determine the best conditions for collecting and processing blood cells intended for testing the function of LRRK2, a protein...
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Our funding programs support basic, translational and clinical research from academia and industry.