The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2016Structure Window into LRRK2: Kinase or Pseudokinase?
Study Rationale:
Our present understanding of LRRK2 is held back by a lack of structural information. Our
interdisciplinary team will solve structures of specific familial (inherited) mutants of LRRK2... -
Research Grant, 2016Structural Studies on LRRK2 Kinase Using X-Ray Crystallography
Promising Outcomes of Original Grant:
Our initial grant, led by Dr. Susan Taylor, focused on the structural organization of a protein called LRRK2, an enzyme that transfers small chemical groups called... -
Research Grant, 2016Characterization, Optimization and Validation of a Preformed Fibril Pre-clinical Model of Parkinson's Disease
Study Rationale:
New pre-clinical models have been developed to study the hypothesis that damaging forms of alpha-synuclein (protein involved in Parkinson's) spread across brain regions from a single... -
Research Grant, 2016Design and Identification of a LRRK2 Kinase Structural Surrogate
Study Rationale:
Due to the importance of the LRRK2 protein in Parkinson's disease (PD), many academic and industrial laboratories have attempted to solve the three-dimensional structure of the kinase...
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Access to Data and Biospecimens, 2016Evaluation of Glucocerebrosidase Pathway Biomarkers in Parkinson's Disease
Study Rationale:
Parkinson disease (PD) due to monoallelic glucocerebrosidase (GBA1) gene mutations (GBA-PD) is at the forefront of novel approaches to the treatment of PD. Exciting potential...
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Research Grant, 2016Electrical Stimulation of the Brain as Parkinson's Disease Treatment
Study Rationale:
Depression is a common non-motor symptom associated with Parkinson's disease (PD), and impulse control disorders (ICDs) are behaviors that may arise with use of certain PD medications...
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Our funding programs support basic, translational and clinical research from academia and industry.