The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2017Validation of the Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) for Parkinson's Disease
Study Rationale:
The US Food and Drug (FDA) requires acceptable outcome measures to approve a cognitive-enhancing medication for the treatment of mild cognitive impairment (MCI) in Parkinson's disease... -
Research Grant, 2017A Proof-of-Concept Study of Mitochondrial Drugs in Pre-Clinical Models of Parkinson’s Disease
Study Rationale:
Mitochondrial dysfunction (powerhouse of the cell), free-radical induced injury (highly reactive atoms that can be harmful) and inflammatory mechanisms have been proposed to play a... -
Research Grant, 2017From Nose to Diagnostics: Development of an Accessible Screening Platform for Early Diagnosis of Parkinson's Disease
Study Rationale:
The aim of this study is to determine if chemicals found on the skin of those with Parkinson's disease (PD) can be used as a way to diagnose PD before motor symptoms develop. We have... -
Research Grant, 2016Rab Detection Initiative and LRRK2 Detection Initiative Supplemental Support RDI, and LCC exosome replication
Study Rationale:
The LRRK2 detection initiative (LDI) and Rab detection initiative (RDI) are focused on developing techniques for the robust and sensitive detection of LRRK2, phospho-LRRK2, Rab and... -
Research Grant, 2016LRRK2 Biomarker Initiative: Detection of LRRK2 in Cerebrospinal Fluid
Study Rationale:
Recent studies indicate the potential use of LRRK2 or LRRK2 phosphorylation (protein regulation) in biosamples as disease markers or as markers of response to novel therapeutics... -
Research Grant, 2016Mechanisms of LRRK2 Membrane Association
Promising Outcomes of Original Grant:
We have verified that LRRK2 undergoes key changes that affect LRRK2 structure and LRRK2 membrane localization. We have generated a large set of LRRK2 variants...
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Our funding programs support basic, translational and clinical research from academia and industry.