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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2018
    Discovery and Development of Novel Parkin Activators

    Study Rationale:
    Parkinson's disease is characterized by a loss of nerve cells (neurons) in the brain resulting potentially from their inability to remove damaged mitochondria, which control energy...

  • Research Grant, 2018
    Developing Biosignatures of Parkinson's Disease Using Sense of Smell Supplement

    Promising Outcomes of Original Grant:
    Recent reports of people with “super-smelling powers” have triggered the idea that there exists a specific scent in Parkinson’s patients’ sebum, an oily skin...

  • Target Advancement Program, 2018
    Evaluation of PARIS ASOs in Models of Parkinson's Disease

    Study Rationale:
    The parkin-interacting substrate (PARIS) prevents genes that are important in the survival of dopamine neurons from working by limiting their expression in neurons. Previously we...

  • Therapeutic Pipeline Program, 2018
    Bitopertin to Alleviate Dyskinesia in Parkinson's Disease

    Study Rationale:
    Levodopa-induced dyskinesia is abnormal involuntary movements that can affect people with Parkinson's disease after years of treatment. Available therapies for dyskinesia are only...

  • Research Grant, 2018
    pS65-Ub as a Biomarker for Parkinson's Disease

    Study Rationale:
    The PINK1 and parkin proteins jointly ensure quality control of mitochondria, the cell's powerhouse. Together they modify damaged mitochondria with phosphorylated ubiquitin (pS65-Ub)...

  • Research Grant, 2018
    Exploring the Effect of Altitude on Parkinson's Disease

    Study Rationale:
    There is a lot of anecdotal evidence that the symptoms of Parkinson's disease (PD) may improve markedly during visits to high-altitude destinations. Given the significant, but as yet...

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